Fildena is a highly effective medication formulated to treat erectile dysfunction (ED) in men. It contains Sildenafil Citrate, the same active ingredient found in high-cost ED medications such as Viagra. Fildena works by enhancing blood flow to the penile area, thereby helping men achieve and maintain a firm erection suitable for sexual activity.

Proven Efficacy of Fildena in Treating ED

• Clinical Studies: Clinical trials on Sildenafil Citrate have proved significant improvement in erectile function. These studies show that Sildenafil helps achieve successful intercourse in 60-70% of men with ED.
• Rapid Onset and Long Duration: Fildena dissolves quickly and acts within 30 to 60 minutes after intake. Its effects can last up to 4 to 6 hours, allowing for a more spontaneous and natural sexual experience.
• Versatility in Strengths: To treat different levels of erectile dysfunction severity, Fildena tablets are available in 25 mg, 50 mg, 100 mg, 120 mg, 150 mg, and Fildena 200. This versatility ensures that men can find a dosage that works best for their condition and tolerance.
• High Success Rate: Studies indicate that men who use Fildena experience a significant improvement in their ability to achieve and maintain an erection to satisfy sexual desire. This high success rate contributes to its popularity and trust among users.

Forms and Strengths of Fildena

Fildena is available in various forms and strengths to suit different needs and preferences:

• Fildena 25 mg: Ideal for men who are trying Sildenafil for the first time or those who require a lower dose. Once daily and about 30-60 minutes before sexual activity.
• Fildena 50 mg: A common starting dose for many men. Taken 30-60 minutes before sexual activity and only one dose per day.
• Fildena 100 mg: Suitable for men who did not achieve the desired effect with lower doses. Consuming approximately 30-60 minutes before sexual activity is best preferred.
• Fildena 120 mg: For men who require a higher dose to achieve an erection. Only to be used under medical supervision, typically taken once daily.
• Fildena 150 mg: For men with severe ED who did not respond to lower doses. Used under strict medical guidance, taken once daily.
• Fildena 200 mg: The highest strength, for cases where other doses are ineffective. Such a high dose of Fildena must be prescribed and monitored by a healthcare professional.
• Fildena CT (Chewable Tablets): Available in 50 mg and 100 mg. Easy to consume and acts faster as it’s absorbed through the mouth. Taken as needed, typically one tablet 30-60 minutes before sexual activity.
• Fildena XXX (Soft Tablets): Available in 100 mg. Dissolves quickly in the mouth for a faster onset of action. Taken as needed, usually one tablet 30-60 minutes before sexual activity.

When to Use Each Strength

• Low Strength (25 mg, 50 mg): Recommended for beginners or those with mild ED.
• Moderate Strength (100 mg): For regular use when lower doses are ineffective.
• High Strength (120 mg, 150 mg, 200 mg): Always under medical supervision for severe ED or when other doses are ineffective.

Importance of Medical Guidance

• Consult a Healthcare Professional: Before starting Fildena, it’s essential to consult a healthcare provider. Based on your medical history, current medications, and overall health, medical experts can better define if this medicine is suitable.
• Personalized Dosage: A doctor can prescribe the appropriate dosage based on your specific condition and response to the medication. Self-medicating or adjusting your dose without professional advice can lead to adverse effects.

How Fildena Works?

Fildena, containing the active ingredient Sildenafil Citrate, works through a series of biochemical reactions that ultimately lead to an erection.

Mechanism of Action

1)  PDE5 Inhibition

• Enzyme Inhibition: Sildenafil Citrate is a selective inhibitor of the enzyme phosphodiesterase type 5 (PDE5). PDE5 is primarily found in the corpus cavernosum of the penis.
• cGMP Breakdown: Under normal circumstances, PDE5 breaks down cyclic guanosine monophosphate (cGMP), a molecule that plays a crucial role in regulating blood flow in the penis.

2) cGMP Accumulation

• Nitric Oxide Release: Sexual stimulation leads to the release of nitric oxide (NO) in the corpus cavernosum. NO activates the enzyme guanylate cyclase, resulting in increased levels of cGMP.
• Smooth Muscle Relaxation: cGMP causes the smooth muscle cells in the walls of the blood vessels in the penis to relax. This relaxation allows blood to flow more freely into the corpus cavernosum.

3) Enhanced Blood Flow

Erection Achievement: As the blood vessels dilate and the blood flow increases, the penis becomes engorged with blood, leading to an erection. The increased blood flow is what makes the penis firm and erect.

Maintaining the Erection:

• Sustained cGMP Levels: By inhibiting PDE5, Sildenafil prevents the breakdown of cGMP. This prolongs the duration of cGMP’s action, allowing for a sustained erection as long as sexual arousal continues.
• Detumescence: After ejaculation or the cessation of sexual stimulation, cGMP levels decrease, PDE5 resumes its activity, and the erection subsides.

Metabolism and Excretion

• Metabolism: Sildenafil is primarily metabolized in the liver by the enzymes CYP3A4 and CYP2C9.
• Excretion: The metabolites of Sildenafil are excreted through the feces (approximately 80%) and urine (approximately 13%).

Dosage and Administration

Intake

• Starting Dose: Starting with a basic dose of 25 mg or 50 mg, taken as needed about 30-60 minutes before sexual activity. Depending on the effectiveness and tolerance, your doctor may adjust the dose or increase it to 100 mg.
• Maximum Dose: Do not exceed 200 mg in a single day. High doses increase the risk of side effects without significantly improving efficacy.
• Method of Intake: Include a glass of water to swallow the tablet whole. For chewable or soft tablet forms, follow specific instructions provided with the product.

Timing

• Onset of Action: The effect of the medicine can be experienced within 30-60 minutes of consumption.
• Duration: Its effects can last up to 4 to 6 hours, depending on individual metabolism and other factors.

Food and Alcohol

• Food: Fildena tablets are safe to consume with or without food. However, avoid a high-fat meal as it can delay its onset.
• Alcohol: A combination of alcohol and Fildena can reduce the effectiveness of the medication or increase the likelihood of side effects. Hence, avoid or limit alcohol consumption.

Common side effects include

• Headache
• Flushing
• Indigestion
• Nasal congestion
• Dizziness
• Visual disturbances

Severe Side Effects (Rare)

Priapism: An erection lasting more than four hours. Seek immediate medical help to prevent long-term damage.
Severe Hypotension: Markedly low blood pressure, especially if taken with nitrates.
Heart Attack Symptoms: Chest pain, shortness of breath, and nausea.
Sudden Vision Loss: Loss of vision in one or both eyes.

If any of these effects persist or worsen, contact your healthcare provider.

Precautions

Medical Conditions:

Inform your doctor if you have any of the following:
Heart disease or conditions affecting heart rhythm
Recent history of stroke or heart attack
High or low blood pressure
Liver or kidney disease
Retinitis pigmentosa (a rare inherited eye disease)
Severe vision loss or conditions affecting the optic nerve

Drug Interactions

Provide a complete list of medications you are taking, especially:

• Nitrates for chest pain
• Alpha-blockers for prostate or blood pressure issues
• Other ED treatments
• HIV protease inhibitors
• Certain antibiotics and antifungals

Avoiding Contraindications: Do not use Fildena if taking nitrates, nitric oxide donors, or any medications that can interact with Sildenafil Citrate. The combination can cause a dangerous drop in blood pressure or other side effects on health.